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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-9-11
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pubmed:abstractText |
Overexpression of P-glycoprotein (P-gp), the protein product of the multidrug resistance gene (MDR1), confers a drug resistant phenotype on cells. We have recently demonstrated that the MDR1 promoter is transcriptionally activated by the HTLV-I tax protein, providing an explanation for the development of drug resistance in HTLV-I infections. Here we report that HTLV-I mediated MDR1 activation is dependent on the presence of an NF-IL6-binding site located between base pairs -148 and -141 relative to the transcription start site. This finding opens up the possibility of moderating P-gp expression through interference with NF-IL6 binding to its trans recognition element and subsequent repression of MDR1 transcription.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
249
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-404
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9712708-Adaptor Protein Complex alpha Subunits,
pubmed-meshheading:9712708-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:9712708-Animals,
pubmed-meshheading:9712708-Binding Sites,
pubmed-meshheading:9712708-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:9712708-COS Cells,
pubmed-meshheading:9712708-DNA-Binding Proteins,
pubmed-meshheading:9712708-Gene Deletion,
pubmed-meshheading:9712708-Gene Expression,
pubmed-meshheading:9712708-Gene Products, tax,
pubmed-meshheading:9712708-Genes, MDR,
pubmed-meshheading:9712708-Human T-lymphotropic virus 1,
pubmed-meshheading:9712708-Membrane Proteins,
pubmed-meshheading:9712708-Mutagenesis, Site-Directed,
pubmed-meshheading:9712708-Nuclear Proteins,
pubmed-meshheading:9712708-P-Glycoprotein,
pubmed-meshheading:9712708-Promoter Regions, Genetic,
pubmed-meshheading:9712708-Transcription, Genetic,
pubmed-meshheading:9712708-Transcriptional Activation
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pubmed:year |
1998
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pubmed:articleTitle |
The mechanism of trans-activation of the MDR1 gene by human T-cell leukemia virus.
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pubmed:affiliation |
Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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