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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0012091,
umls-concept:C0019552,
umls-concept:C0022742,
umls-concept:C0029408,
umls-concept:C0034656,
umls-concept:C0087111,
umls-concept:C0210355,
umls-concept:C0717703,
umls-concept:C1257890,
umls-concept:C1696465,
umls-concept:C1707455,
umls-concept:C2587213,
umls-concept:C2603343
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|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1998-10-30
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|
pubmed:abstractText |
Gastric (GU) and duodenal ulcers (DU) are common adverse effects of nonsteroidal anti-inflammatory drugs (NSAID). Endoscopically diagnosed upper gastrointestinal (GI) ulceration occurs in about 24% of longterm NSAID users. Coadministration of misoprostol with the NSAID reduces the incidence of NSAID induced GU and DU and their complications. However, compliance is limited by the different dosing regimens of misoprostol and NSAID and GI symptoms associated with misoprostol at its recommended q.i.d. dose. We compared the efficacy, safety, and incidence of endoscopic upper GI ulceration associated with the administration of 2 combinations of diclofenac (50 or 75 mg) and misoprostol 200 microg (D50/M200 t.i.d., D75/M200 b.i.d.), diclofenac 75 mg b.i.d., and placebo in a 6 week, randomized, double blind study in patients with osteoarthritis (OA) of the knee or hip.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
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|
pubmed:issn |
0315-162X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
25
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1602-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9712107-Adult,
pubmed-meshheading:9712107-Aged,
pubmed-meshheading:9712107-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9712107-Diclofenac,
pubmed-meshheading:9712107-Double-Blind Method,
pubmed-meshheading:9712107-Drug Therapy, Combination,
pubmed-meshheading:9712107-Duodenal Ulcer,
pubmed-meshheading:9712107-Endoscopy, Gastrointestinal,
pubmed-meshheading:9712107-Female,
pubmed-meshheading:9712107-Humans,
pubmed-meshheading:9712107-Male,
pubmed-meshheading:9712107-Middle Aged,
pubmed-meshheading:9712107-Misoprostol,
pubmed-meshheading:9712107-Osteoarthritis, Hip,
pubmed-meshheading:9712107-Osteoarthritis, Knee,
pubmed-meshheading:9712107-Outcome Assessment (Health Care),
pubmed-meshheading:9712107-Stomach Ulcer,
pubmed-meshheading:9712107-Treatment Failure
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pubmed:year |
1998
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|
pubmed:articleTitle |
Diclofenac/misoprostol compared with diclofenac in the treatment of osteoarthritis of the knee or hip: a randomized, placebo controlled trial. Arthrotec Osteoarthritis Study Group.
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pubmed:affiliation |
Arthritis Center of Nebraska, Lincoln, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
