Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-8-27
|
| pubmed:abstractText |
T cells infiltrating the iris/ciliary body of Lewis rats with anterior uveitis (AU) that had been induced by myelin basic protein (MBP) immunization were previously found to share surface markers common to the T cells that cause experimental autoimmune encephalomyelitis (EAE). To determine whether these AU-associated T cells are in fact the same as those that infiltrate the central nervous system to cause EAE, we examined TCR V gene expression in T cells infiltrating the anterior chamber in rats with AU. As with EAE, we found a biased expression of Vbeta8.2 and Valpha2 in the iris/ciliary body and, although one would expect an influx of nonspecific inflammatory T cells, these biases were still evident at the peak of AU. An analysis of the TCR Vbeta8.2 and Valpha2 sequences derived from the iris/ciliary body demonstrated the presence of the same complementarity determining region 3 motifs found in MBP-specific T cells that are pathogenic for EAE and found in T cells derived from the central nervous system of rats with EAE. Finally, T cells isolated from the iris/ciliary body of rats with AU were found to proliferate in a specific fashion to MBP Ags. Thus, it appears that MBP-specific T cells are pathogenic for AU as well as EAE in the Lewis rat. In addition, the long-term presence of this highly restricted MBP response in the iris/ciliary body indicates that distinct immunoregulatory mechanisms exist in the environment of the eye. This provides an interesting model with which to address questions pertaining to the nature of T cells infiltrating the eye and their regulation during EAE and other systemic diseases.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
161
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2052-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9712079-Animals,
pubmed-meshheading:9712079-Cell Movement,
pubmed-meshheading:9712079-Ciliary Body,
pubmed-meshheading:9712079-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:9712079-Epitopes, T-Lymphocyte,
pubmed-meshheading:9712079-Female,
pubmed-meshheading:9712079-Gene Expression Regulation,
pubmed-meshheading:9712079-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:9712079-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:9712079-Guinea Pigs,
pubmed-meshheading:9712079-Iris,
pubmed-meshheading:9712079-Lymphocyte Activation,
pubmed-meshheading:9712079-Myelin Basic Proteins,
pubmed-meshheading:9712079-Rats,
pubmed-meshheading:9712079-Rats, Inbred Lew,
pubmed-meshheading:9712079-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9712079-Spinal Cord,
pubmed-meshheading:9712079-T-Lymphocyte Subsets,
pubmed-meshheading:9712079-Uveitis, Anterior
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
EAE TCR motifs and antigen recognition in myelin basic protein-induced anterior uveitis in Lewis rats.
|
| pubmed:affiliation |
Department of Neurology, Oregon Health Sciences University, Portland 97201, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|