Linked Life Data

9711994

Source:http://linkedlifedata.com/resource/pubmed/id/9711994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-8-28
pubmed:abstractText
Production rates of cortisol were determined in healthy men (n = 7) and in healthy women during the follicular phase of their menstrual cycle (n = 7) using the stable-isotope dilution technique and analysis by gas chromatography/mass spectrometry (GC/MS). 1Alpha,2alpha-D-Cortisol was infused for 10 hours (116 +/- 6 microg/h; 8 AM to 6 PM). Blood samples obtained at 20-minute intervals during the last 4 hours (2 PM to 6 PM) were pooled and used for analysis. Estimated production rates of cortisol were 0.94 +/- 0.15 mg/h and 0.38 +/- 0.14 mg/h in healthy men and women, respectively. Even when corrected for body-surface area, production rates of cortisol in men (0.48 +/- 0.09 mg/m2 x h) were higher (P < .001) than in women (0.22 +/- 0.08 mg/m2 x h). An increased production rate of cortisol was seen in 12 patients with Cushing's syndrome, although in four of nine female patients, it was within the range considered normal for healthy men. It is concluded that women have a lower production of cortisol than men and that this sex-specific difference is of clinical relevance in patients with endogenous hypercortisolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
974-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Sex-specific differences in cortisol production rates in humans.
pubmed:affiliation
Department of Internal Medicine III, University of Vienna, Austria.
pubmed:publicationType
Journal Article