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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-10-20
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pubmed:abstractText |
The enzyme lecithin-cholesterol acyl transferase (LCAT) esterifies free cholesterol on high-density lipoprotein (HDL) and the cholesteryl ester transfer protein (CETP) transfers cholesteryl ester to very-low-density lipoprotein (VLDL) and low-density lipoproteins (LDL). Using statins, contradictory findings have been made regarding CETP activity in normolipidemic individuals and in those with familial dysbetalipoproteinemia. In contrast, LCAT activity appears to be unaffected by simvastatin. Antioxidants have also been proposed for the use of anti-atherosclerotic treatment, because the oxidation of LDL may have a key role in the pathophysiology of atherogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0954-6928
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pubmed:author |
pubmed-author:AbetePP,
pubmed-author:CacciatoreFF,
pubmed-author:ChiarielloMM,
pubmed-author:ChiarielloPP,
pubmed-author:D'ArmientoF PFP,
pubmed-author:De MatteisCC,
pubmed-author:Di LoretoMM,
pubmed-author:LecceseMM,
pubmed-author:LiguoriAA,
pubmed-author:NapoliCC,
pubmed-author:PalumboGG,
pubmed-author:SommoFF,
pubmed-author:ZulianiPP,
pubmed-author:de NigrisFF
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9710685-Antioxidants,
pubmed-meshheading:9710685-Carrier Proteins,
pubmed-meshheading:9710685-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:9710685-Combined Modality Therapy,
pubmed-meshheading:9710685-Drug Therapy, Combination,
pubmed-meshheading:9710685-Female,
pubmed-meshheading:9710685-Glycoproteins,
pubmed-meshheading:9710685-Humans,
pubmed-meshheading:9710685-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:9710685-Hypercholesterolemia,
pubmed-meshheading:9710685-Male,
pubmed-meshheading:9710685-Phosphatidylcholine-Sterol O-Acyltransferase,
pubmed-meshheading:9710685-Pravastatin,
pubmed-meshheading:9710685-Vitamin E
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pubmed:year |
1998
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pubmed:articleTitle |
Effects of vitamin E and HMG-CoA reductase inhibition on cholesteryl ester transfer protein and lecithin-cholesterol acyltransferase in hypercholesterolemia.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine, University of Naples, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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