| pubmed-article:9710606 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9710606 | lifeskim:mentions | umls-concept:C0376526 | lld:lifeskim |
| pubmed-article:9710606 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9710606 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:9710606 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9710606 | lifeskim:mentions | umls-concept:C1521889 | lld:lifeskim |
| pubmed-article:9710606 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9710606 | pubmed:dateCreated | 1998-9-10 | lld:pubmed |
| pubmed-article:9710606 | pubmed:abstractText | Kaposi's sarcoma-associated herpesvirus (KSHV) is consistently identified in Kaposi's sarcoma and body cavity-based lymphoma. KSHV encodes a transforming protein called K1 which is structurally similar to lymphocyte receptors. We have found that a highly conserved region of the cytoplasmic domain of K1 resembles the sequence of immunoreceptor tyrosine-based activation motifs (ITAMs). To demonstrate the signal-transducing activity of K1, we constructed a chimeric protein in which the cytoplasmic tail of the human CD8alpha polypeptide was replaced with that of KSHV K1. Expression of the CD8-K1 chimera in B cells induced cellular tyrosine phosphorylation and intracellular calcium mobilization upon stimulation with an anti-CD8 antibody. Mutational analyses showed that the putative ITAM of K1 was required for its signal-transducing activity. Furthermore, tyrosine residues of the putative ITAM of K1 were phosphorylated upon stimulation, and this allowed subsequent binding of SH2-containing proteins. These results demonstrate that the KSHV transforming protein K1 contains a functional ITAM in its cytoplasmic domain and that it can transduce signals to induce cellular activation. | lld:pubmed |
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| pubmed-article:9710606 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9710606 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710606 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9710606 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9710606 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9710606 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:LeeHH | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:MADD | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:GutMM | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:RosenzweigMM | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:ChoiJ KJK | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:JungJ UJU | lld:pubmed |
| pubmed-article:9710606 | pubmed:author | pubmed-author:DeMariaMM | lld:pubmed |
| pubmed-article:9710606 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9710606 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9710606 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9710606 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9710606 | pubmed:pagination | 5219-28 | lld:pubmed |
| pubmed-article:9710606 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9710606 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9710606 | pubmed:articleTitle | Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. | lld:pubmed |
| pubmed-article:9710606 | pubmed:affiliation | Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA. | lld:pubmed |
| pubmed-article:9710606 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9710606 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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