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pubmed-article:9709709pubmed:abstractTextKidney biopsies were undertaken for persisting proteinuria 3.3 to 7 years (mean 5.4 years) from the onset of diarrhea-associated hemolytic uremic syndrome (D + HUS) in 5 boys and 2 girls (age at presentation mean 3.2 years, range 1.0 to 9.7 years). At 1 year the mean early morning urine protein/creatinine ratio was 100 mg/mmol, and the mean glomerular filtration rate was 65 mL/min/1.73 m2. At 5 years the mean early morning urine protein/creatinine ratio was 81 mg/mmol, and the mean glomerular filtration rate was 73 mL/min/1.73 m2. The biopsy specimens were compared with those of 7 age- and sex-matched children who were investigated for isolated persistent microscopic hematuria but in whom no abnormality was detected. Global glomerulosclerosis was noted in 6 patients with D + HUS, and 2 of these had segmental sclerosing lesions. Tubular atrophy and interstitial scarring were seen in all but 1 patients. The glomeruli in the D + HUS group were significantly larger than in the control group (P < .01). These findings are typically found in kidneys with reduced nephron numbers and are compatible with changes of hyperperfusion and hyperfiltration in surviving nephrons. Long-term follow-up of patients with D + HUS and proteinuria is advisable.lld:pubmed
pubmed-article:9709709pubmed:languageenglld:pubmed
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pubmed-article:9709709pubmed:authorpubmed-author:TaylorC MCMlld:pubmed
pubmed-article:9709709pubmed:authorpubmed-author:HowieA JAJlld:pubmed
pubmed-article:9709709pubmed:authorpubmed-author:FerreiraM AMAlld:pubmed
pubmed-article:9709709pubmed:authorpubmed-author:MoghalN ENElld:pubmed
pubmed-article:9709709pubmed:authorpubmed-author:MilfordD VDVlld:pubmed
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pubmed-article:9709709pubmed:volume133lld:pubmed
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pubmed-article:9709709pubmed:pagination220-3lld:pubmed
pubmed-article:9709709pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:9709709pubmed:year1998lld:pubmed
pubmed-article:9709709pubmed:articleTitleThe late histologic findings in diarrhea-associated hemolytic uremic syndrome.lld:pubmed
pubmed-article:9709709pubmed:affiliationDepartment of Pathology, Children's Hospital, University of Birmingham, United Kingdom.lld:pubmed
pubmed-article:9709709pubmed:publicationTypeJournal Articlelld:pubmed
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