Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-9-3
|
| pubmed:abstractText |
Kidney biopsies were undertaken for persisting proteinuria 3.3 to 7 years (mean 5.4 years) from the onset of diarrhea-associated hemolytic uremic syndrome (D + HUS) in 5 boys and 2 girls (age at presentation mean 3.2 years, range 1.0 to 9.7 years). At 1 year the mean early morning urine protein/creatinine ratio was 100 mg/mmol, and the mean glomerular filtration rate was 65 mL/min/1.73 m2. At 5 years the mean early morning urine protein/creatinine ratio was 81 mg/mmol, and the mean glomerular filtration rate was 73 mL/min/1.73 m2. The biopsy specimens were compared with those of 7 age- and sex-matched children who were investigated for isolated persistent microscopic hematuria but in whom no abnormality was detected. Global glomerulosclerosis was noted in 6 patients with D + HUS, and 2 of these had segmental sclerosing lesions. Tubular atrophy and interstitial scarring were seen in all but 1 patients. The glomeruli in the D + HUS group were significantly larger than in the control group (P < .01). These findings are typically found in kidneys with reduced nephron numbers and are compatible with changes of hyperperfusion and hyperfiltration in surviving nephrons. Long-term follow-up of patients with D + HUS and proteinuria is advisable.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-3476
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
133
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
220-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9709709-Biopsy,
pubmed-meshheading:9709709-Child,
pubmed-meshheading:9709709-Child, Preschool,
pubmed-meshheading:9709709-Diarrhea,
pubmed-meshheading:9709709-Female,
pubmed-meshheading:9709709-Hemolytic-Uremic Syndrome,
pubmed-meshheading:9709709-Humans,
pubmed-meshheading:9709709-Infant,
pubmed-meshheading:9709709-Kidney,
pubmed-meshheading:9709709-Kidney Glomerulus,
pubmed-meshheading:9709709-Male,
pubmed-meshheading:9709709-Proteinuria,
pubmed-meshheading:9709709-Time Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
The late histologic findings in diarrhea-associated hemolytic uremic syndrome.
|
| pubmed:affiliation |
Department of Pathology, Children's Hospital, University of Birmingham, United Kingdom.
|
| pubmed:publicationType |
Journal Article
|