Linked Life Data

9709376

Source:http://linkedlifedata.com/resource/pubmed/id/9709376

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-10-23
pubmed:abstractText
The origin and development of the spermatogenic cell lineage is reviewed, as well as spermatogonial kinetics in adult nonprimate mammals in relation to the cycle of the seminiferous epithelium, the emphasis being on spermatogonial stem cells. A hypothesis is presented for the transition from foetal germ cells, gonocytes, to adult type spermatogonia at the start of spermatogenesis. An overview is given of the present knowledge on the proliferation and differentiation of undifferentiated spermatogonia (spermatogonial stem cells and their direct descendants) and the regulation of these processes. It is concluded that the differentiation of the undifferentiated into differentiating type spermatogonia is a rather vulnerable moment during spermatogenesis and the models for studying this are described. Research into the molecular basis of the regulation of spermatogonial proliferation, differentiation and apoptosis is at its infancy and the first results are reviewed. An exciting new research tool is the spermatogonial stem cell transplantation technique which is described. Finally, reviewing the nature of human germ cell tumours it is concluded that at present there are no animal or in vitro models to study these tumours experimentally.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0959-9673
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-80
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Stem cells in the testis.
pubmed:affiliation
Department of Cell Biology, Utrecht University, The Netherlands. d.g.derooij@med.ruu.nl
pubmed:publicationType
Journal Article, Review