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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-9-21
|
| pubmed:abstractText |
Bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate was prepared as a prodrug to generate 2'-azido-2'-deoxyuridine 5'-diphosphate inside the cell. A synthetic route utilizing stannyl phosphate was adopted in the preparation. The prodrug was evaluated for cell growth inhibition against a variety of tumor cell lines along with 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0732-8311
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1089-98
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9708324-Animals,
pubmed-meshheading:9708324-Antineoplastic Agents,
pubmed-meshheading:9708324-Azides,
pubmed-meshheading:9708324-CHO Cells,
pubmed-meshheading:9708324-Cricetinae,
pubmed-meshheading:9708324-Deoxyuracil Nucleotides,
pubmed-meshheading:9708324-Drug Screening Assays, Antitumor,
pubmed-meshheading:9708324-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9708324-Tumor Cells, Cultured
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis and biological activity of bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate.
|
| pubmed:affiliation |
School of Pharmacy, University of North Carolina, Chapel Hill 27514, USA.
|
| pubmed:publicationType |
Journal Article
|