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pubmed-article:9707639pubmed:abstractTextRotating waves (rotors) of cellular activity were observed in nonconfluent cultures of embryonic chick heart cells by using a macroscopic imaging system that detected fluorescence from intracellular Ca2+. Unlike previous observations of rotors or spiral waves in other systems, the rotors did not persist but exhibited a repetitive pattern of spontaneous onset and offset leading to a bursting rhythm. Similar dynamics were observed in a cellular automaton model of excitable media that incorporates spontaneous initiation of activity, and a decrease of excitability as a consequence of rapid activity (fatigue). These results provide a mechanism for bursting dynamics in normal and pathological biological processes.lld:pubmed
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pubmed-article:9707639pubmed:articleTitleBursting calcium rotors in cultured cardiac myocyte monolayers.lld:pubmed
pubmed-article:9707639pubmed:affiliationDepartment of Physiology, McGill University, 3655 Drummond Street, Montreal, QC Canada, H3G 1Y6.lld:pubmed
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