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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1998-9-17
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pubmed:abstractText |
Rotating waves (rotors) of cellular activity were observed in nonconfluent cultures of embryonic chick heart cells by using a macroscopic imaging system that detected fluorescence from intracellular Ca2+. Unlike previous observations of rotors or spiral waves in other systems, the rotors did not persist but exhibited a repetitive pattern of spontaneous onset and offset leading to a bursting rhythm. Similar dynamics were observed in a cellular automaton model of excitable media that incorporates spontaneous initiation of activity, and a decrease of excitability as a consequence of rapid activity (fatigue). These results provide a mechanism for bursting dynamics in normal and pathological biological processes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-14118488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-1646657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-1720583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-1725879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-1731248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-1905769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-2011747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-2085529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-2321017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-2364495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-2442361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-2450696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-7313693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-7365802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-7473686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-7527077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-8577731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-9252472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9707639-939001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10283-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9707639-Animals,
pubmed-meshheading:9707639-Arrhythmias, Cardiac,
pubmed-meshheading:9707639-Calcium,
pubmed-meshheading:9707639-Cells, Cultured,
pubmed-meshheading:9707639-Chick Embryo,
pubmed-meshheading:9707639-Fluorescence,
pubmed-meshheading:9707639-Heart,
pubmed-meshheading:9707639-Humans,
pubmed-meshheading:9707639-Intracellular Fluid,
pubmed-meshheading:9707639-Ion Transport,
pubmed-meshheading:9707639-Models, Cardiovascular,
pubmed-meshheading:9707639-Myocardium,
pubmed-meshheading:9707639-Periodicity
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pubmed:year |
1998
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pubmed:articleTitle |
Bursting calcium rotors in cultured cardiac myocyte monolayers.
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pubmed:affiliation |
Department of Physiology, McGill University, 3655 Drummond Street, Montreal, QC Canada, H3G 1Y6.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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