Linked Life Data

9707332

Source:http://linkedlifedata.com/resource/pubmed/id/9707332

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-11-18
pubmed:abstractText
Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive fibrohistiocytic tumor of intermediate malignancy with potential for local recurrences and with a small, but well recognized risk of distant metastases. We report a case of a 43-year-old Filipino male with an otherwise typical cutaneous DFSP followed 4 years later by a local recurrence of tumor with subsequent pulmonary metastasis at year 5, and 3 sequential central nervous system (CNS) metastases at years 5, 6, and 12 following the original diagnosis of DFSP. Recurrent and metastatic tumors showed areas of fibrosarcomatous change, high cellularity, high mitotic rate (10 - 15 per 10 high power fields), loss of CD34 expression, and aneuploidy. DFSP has not been previously reported to metastasize to the CNS. In addition, we report complex karyotypic aberrations within the metastasis, which have not been previously associated with DFSP. The dural-based location of the intracranial metastasis, together with the light- and electron-microscopic appearance, could cause diagnostic confusion with an anaplastic syncytial meningioma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0722-5091
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-3
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Metastatic dermatofibrosarcoma protuberans mimicking meningioma.
pubmed:affiliation
Calgary Laboratory Serviers, Pathology Department, Foothills Hospital, Alberta, Canada.
pubmed:publicationType
Journal Article, Case Reports