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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-8-28
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pubmed:abstractText |
Neurotensin, an important gut hormone, binds its receptor (NTR) to stimulate proliferation of intestinal cells; the molecular mechanisms remain largely undefined. Mitogen-activated protein kinases (MAPKs) translocate to the nucleus and induce transcription factors (eg, c-Fos) in response to certain trophic agents. The purpose of this study was (1) to define the signaling mechanisms regulating neurotensin and (2) to determine whether the AP-1 transcription factor c-Fos is induced.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-46; discussion 246-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9706144-Blotting, Northern,
pubmed-meshheading:9706144-Blotting, Western,
pubmed-meshheading:9706144-Calcium,
pubmed-meshheading:9706144-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9706144-Colonic Neoplasms,
pubmed-meshheading:9706144-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9706144-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9706144-Humans,
pubmed-meshheading:9706144-Neurotensin,
pubmed-meshheading:9706144-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:9706144-RNA, Messenger,
pubmed-meshheading:9706144-Signal Transduction,
pubmed-meshheading:9706144-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Signal transduction mechanisms in neurotensin-mediated cellular regulation.
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pubmed:affiliation |
Department of Surgery, University of Texas Medical Branch, Galveston 77555-0533, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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