Linked Life Data

9705113

Source:http://linkedlifedata.com/resource/pubmed/id/9705113

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-9-14
pubmed:abstractText
Sixteen colts were premedicated with acepromazine and anaesthesia was induced with detomidine and ketamine. Ponies were randomly allocated to receive halothane (HAL) or infusion of detomidine, ketamine and guaiphenesin (DKG) to maintain anaesthesia. Heart and respiratory rate, ECG, mean arterial blood pressure (MABP), cardiac index (CI), blood gases and plasma cortisol, ketamine and guaiphenesin were measured. Surgical castration took place between 45 and 75 min and anaesthesia lasted 90 min. MABP with DKG was significantly higher than with HAL, and, with HAL, MABP increased from pre-surgery (64 +/- 6 mmHg) to mid-surgery (80 +/- 5 mmHg) but did not change with DKG. At 30 min, CI was similar in both groups (57 +/- 7 ml/kg bwt/min); it decreased during surgery with HAL and remained low, but it increased slightly with DKG, and was higher than with HAL at 60 and 90 min. Plasma cortisol decreased in both groups until 40 min then increased with HAL only during surgery. Ketamine concentration reached a plateau (1.3-1.8 microg/ml) between 20 and 90 min and guaiphenesin concentration between 60 and 90 min (99-101 microg/ml). Recovery was generally smooth in both groups. This study demonstrated that during HAL the increase in blood pressure associated with surgical stimulus is accompanied by decreased CI; this did not occur during DKG which is likely to lead to better tissue perfusion than HAL. The adrenocortical activity seen during HAL was absent during DKG which may result from pituitary depression, analgesic effects of total intravenous anaesthesia (TIVA) or better perfusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0425-1644
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9705113-Anesthesia, Intravenous, pubmed-meshheading:9705113-Anesthetics, Combined, pubmed-meshheading:9705113-Anesthetics, Dissociative, pubmed-meshheading:9705113-Anesthetics, Inhalation, pubmed-meshheading:9705113-Animals, pubmed-meshheading:9705113-Blood Gas Analysis, pubmed-meshheading:9705113-Blood Pressure, pubmed-meshheading:9705113-Cardiac Output, pubmed-meshheading:9705113-Electrocardiography, pubmed-meshheading:9705113-Guaifenesin, pubmed-meshheading:9705113-Halothane, pubmed-meshheading:9705113-Horses, pubmed-meshheading:9705113-Hydrocortisone, pubmed-meshheading:9705113-Hypnotics and Sedatives, pubmed-meshheading:9705113-Imidazoles, pubmed-meshheading:9705113-Infusions, Intravenous, pubmed-meshheading:9705113-Ketamine, pubmed-meshheading:9705113-Male, pubmed-meshheading:9705113-Orchiectomy, pubmed-meshheading:9705113-Respiration, pubmed-meshheading:9705113-Stroke Volume, pubmed-meshheading:9705113-Vascular Resistance
pubmed:year
1998
pubmed:articleTitle
Cardiovascular effects of surgical castration during anaesthesia maintained with halothane or infusion of detomidine, ketamine and guaifenesin in ponies.
pubmed:affiliation
Department of Clinical Veterinary Medicine, University of Cambridge, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't