Linked Life Data

9705048

Source:http://linkedlifedata.com/resource/pubmed/id/9705048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-11-9
pubmed:abstractText
Normal hypothalamic-pituitary-adrenal (HPA) axis activity is disrupted in several types of human psychiatric disorders, and has been widely reported to be altered as a result of early experience in rodents. In this study the effects of early social experience on later response of the HPA axis to separations from cagemates and pharmacologic treatments were examined in rhesus monkeys. HPA axis activity was measured in mother-reared and peer-reared monkey infants in conjunction with six repeated separations from and reunions with their cagemates. Within each rearing group, infants were assigned to one of three treatment groups that received continuous treatment with either fluoxetine (2 mg/kg), desipramine (DMI, 5 mg/kg) or placebo (saline) beginning 2 weeks prior to separations. At 2 weeks after drug treatment, fluoxetine increased ACTH and cortisol in the treated groups, while DMI decreased ACTH and cortisol in both treated groups; however, these effects were not persistent over the separations. While these treatment effects tended to be more pronounced in the mother-reared group, the rearing groups did not show a clearly differential response to either of the treatments. The most prominent finding was that mother-reared monkeys showed significantly higher ACTH and cortisol levels than peer-reared monkeys over all samples, an effect that may have mitigated a potential rearing group difference in treatment response. The results add to growing evidence for the influence of primate mothers on the functional development of psychobiological systems in their infants, and suggest that the HPA axis is among the more sensitive of these systems to postnatal experience.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-1781
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-104
pubmed:dateRevised
2008-4-17
pubmed:meshHeading
pubmed-meshheading:9705048-Adrenocorticotropic Hormone, pubmed-meshheading:9705048-Analysis of Variance, pubmed-meshheading:9705048-Animals, pubmed-meshheading:9705048-Antidepressive Agents, pubmed-meshheading:9705048-Anxiety, Separation, pubmed-meshheading:9705048-Corticotropin-Releasing Hormone, pubmed-meshheading:9705048-Desipramine, pubmed-meshheading:9705048-Dexamethasone, pubmed-meshheading:9705048-Disease Models, Animal, pubmed-meshheading:9705048-Female, pubmed-meshheading:9705048-Fluoxetine, pubmed-meshheading:9705048-Glucocorticoids, pubmed-meshheading:9705048-Hydrocortisone, pubmed-meshheading:9705048-Hypothalamo-Hypophyseal System, pubmed-meshheading:9705048-Macaca mulatta, pubmed-meshheading:9705048-Male, pubmed-meshheading:9705048-Maternal Deprivation, pubmed-meshheading:9705048-Object Attachment, pubmed-meshheading:9705048-Peer Group, pubmed-meshheading:9705048-Pituitary-Adrenal System, pubmed-meshheading:9705048-Social Environment, pubmed-meshheading:9705048-Social Isolation
pubmed:year
1998
pubmed:articleTitle
Effects of rearing condition on HPA axis response to fluoxetine and desipramine treatment over repeated social separations in young rhesus monkeys.
pubmed:affiliation
Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry and Behavioral Sciences, Northwestern University Medical School, Chicago, IL 60611-3008, USA. sclarke@nwu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't