Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-8-18
pubmed:abstractText
LP-BM5 murine leukemia virus (MuLV) infection causes severe immunodeficiency termed murine AIDS (MAIDS). The acyclic nucleoside phosphonates, (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were examined, in comparison with zidovudine (AZT), for their inhibitory effect on the development of MAIDS. Although no significant difference in inhibition of LP-BM5 MuLV replication was identified between PMPA and PMEA in cell cultures, PMPA was obviously less cytotoxic to the host lymphocytes. None of the mice treated in vivo with 5 or 25 mg/kg of PMPA or 25 mg/kg of PMEA developed MAIDS at 5 weeks after viral infection. However at 9 weeks, none of the 25 mg/kg PMPA-treated mice progressed to MAIDS, except for one that developed mild MAIDS, whereas PMEA, even at 100 mg/kg, could not prevent disease progression. MAIDS-associated activation of lymphocytes and viral replication were drastically inhibited by PMPA treatment. These results indicate that PMPA is a highly effective antiretroviral agent in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1077-9450
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
316-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9704936-Adenine, pubmed-meshheading:9704936-Animals, pubmed-meshheading:9704936-Anti-HIV Agents, pubmed-meshheading:9704936-Cell Survival, pubmed-meshheading:9704936-Clone Cells, pubmed-meshheading:9704936-Female, pubmed-meshheading:9704936-Leukemia Virus, Murine, pubmed-meshheading:9704936-Lymph Nodes, pubmed-meshheading:9704936-Lymphocyte Activation, pubmed-meshheading:9704936-Mice, pubmed-meshheading:9704936-Mice, Inbred C57BL, pubmed-meshheading:9704936-Murine Acquired Immunodeficiency Syndrome, pubmed-meshheading:9704936-Organophosphorus Compounds, pubmed-meshheading:9704936-Phosphonic Acids, pubmed-meshheading:9704936-Specific Pathogen-Free Organisms, pubmed-meshheading:9704936-Spleen, pubmed-meshheading:9704936-Virus Replication, pubmed-meshheading:9704936-Zidovudine
pubmed:year
1998
pubmed:articleTitle
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine.
pubmed:affiliation
Center for Chronic Viral Diseases, First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't