|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1998-8-18
|
|
pubmed:abstractText |
In HIV-1-infected individuals, Fas expression and Fas/FasL-mediated apoptosis of mature T cells are known to increase compared with those in normal individuals. To elucidate a relation between acute HIV-1 infection and the regulation of Fas/FasL system upon T-cell activation, resting CD4+ T cells were acutely infected or uninfected with HIV-1 and subsequently activated by phorbol myristate acetate and ionomycin (PMA/IM). Four days after infection, when HIV-1 env gp120 is expressed in more than one half of activated T cells, Fas/FasL expression was analyzed by flow cytometry, and apoptosis-inducing activity of these activated primary CD4+ T cells on Fas+ Jurkat cells was examined. The level of Fas or FasL expression was not altered during acute HIV-1 infection. The enhanced apoptosis-inducing activity upon HIV-1 infection was observed in some individuals, but its activity was not Fas/FasL-mediated. These results indicate that HIV-1 infection is not necessarily associated with either upregulation of Fas/FasL expression or Fas/FasL-mediated apoptosis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1077-9450
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
307-15
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9704935-Antibodies, Monoclonal,
pubmed-meshheading:9704935-Antigens, CD95,
pubmed-meshheading:9704935-Antigens, Surface,
pubmed-meshheading:9704935-Apoptosis,
pubmed-meshheading:9704935-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9704935-Cell Line,
pubmed-meshheading:9704935-Cells, Cultured,
pubmed-meshheading:9704935-DNA Fragmentation,
pubmed-meshheading:9704935-Fas Ligand Protein,
pubmed-meshheading:9704935-Flow Cytometry,
pubmed-meshheading:9704935-HIV Envelope Protein gp120,
pubmed-meshheading:9704935-HIV-1,
pubmed-meshheading:9704935-Humans,
pubmed-meshheading:9704935-Leukocytes, Mononuclear,
pubmed-meshheading:9704935-Ligands,
pubmed-meshheading:9704935-Lymphocyte Activation,
pubmed-meshheading:9704935-Membrane Glycoproteins,
pubmed-meshheading:9704935-Receptors, Interleukin-2,
pubmed-meshheading:9704935-Up-Regulation
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Fas/FasL interaction is not involved in apoptosis of activated CD4+ T cells upon HIV-1 infection in vitro.
|
|
pubmed:affiliation |
Department of Immunology, AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
