Linked Life Data

9704178

Source:http://linkedlifedata.com/resource/pubmed/id/9704178

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-10-21
pubmed:abstractText
We have reported the results of a previous Phase II trial of two courses of neoadjuvant mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2) (MIC) in squamous or anaplastic carcinoma of the oesophagus. In this current study, we have investigated whether there was any clinical benefit in extending the preoperative treatment to four courses for patients who responded after two courses. Response was assessed by barium swallow, which was compared with previous barium swallows performed prior to any treatment and after the second course of MIC. Of an initial 43 patients, 27 (63%) were assessed as responders after two courses of MIC. Twenty of these 27 patients were entered into the study with a view to receiving two further courses of MIC prior to surgery. Seventeen completed four courses. Five patients were complete responders after two courses and remained complete responders after four courses. Twelve patients were partial responders after two courses; six of these became complete responders after four courses, five remained partial responders, and one showed progression. Haematological toxicity and alopecia were increased after extending the number of courses beyond two. On pathological assessment, three patients with a complete response after four courses, and one with a complete response after three courses, had microscopic clearance of tumour. Extension beyond two courses of neoadjuvant MIC gives an improvement in response, as judged by barium assessment, but increases toxicity, cost of treatment and delay before surgery. Although the numbers are small, the results suggest that a worthwhile improvement in the radiological response of squamous or anaplastic oesophageal tumours may be gained by proceeding beyond two courses of MIC. A randomized trial, with larger numbers of patients, is needed to show whether there is any improvement in radiological and pathological response rates and in survival to be gained by the extension of treatment beyond two courses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0936-6555
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-9
pubmed:dateRevised
2008-3-10
pubmed:meshHeading
pubmed-meshheading:9704178-Adult, pubmed-meshheading:9704178-Aged, pubmed-meshheading:9704178-Alopecia, pubmed-meshheading:9704178-Antibiotics, Antineoplastic, pubmed-meshheading:9704178-Antineoplastic Agents, pubmed-meshheading:9704178-Antineoplastic Agents, Alkylating, pubmed-meshheading:9704178-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:9704178-Barium Sulfate, pubmed-meshheading:9704178-Carcinoma, pubmed-meshheading:9704178-Carcinoma, Squamous Cell, pubmed-meshheading:9704178-Chemotherapy, Adjuvant, pubmed-meshheading:9704178-Cisplatin, pubmed-meshheading:9704178-Contrast Media, pubmed-meshheading:9704178-Drug Administration Schedule, pubmed-meshheading:9704178-Esophageal Neoplasms, pubmed-meshheading:9704178-Female, pubmed-meshheading:9704178-Health Care Costs, pubmed-meshheading:9704178-Hematologic Diseases, pubmed-meshheading:9704178-Humans, pubmed-meshheading:9704178-Ifosfamide, pubmed-meshheading:9704178-Male, pubmed-meshheading:9704178-Middle Aged, pubmed-meshheading:9704178-Mitomycins, pubmed-meshheading:9704178-Randomized Controlled Trials as Topic, pubmed-meshheading:9704178-Remission Induction
pubmed:year
1998
pubmed:articleTitle
A phase II trial of four courses of preoperative chemotherapy in squamous or anaplastic carcinoma of the oesophagus.
pubmed:affiliation
Birmingham Heartlands Hospital, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't, Clinical Trial, Phase II