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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1998-9-8
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pubmed:abstractText |
The spontaneous recovery of nigrostriatal dopaminergic neurons was quantitatively analyzed with tyrosine hydroxylase (TH)-immunocytochemistry in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57BL/6 young mice. A substantial reduction of striatal dopamine (DA) level was observed until 24 days following MPTP treatment. The TH-immunoreactive (IR) fibers and number of TH-positive cell bodies were also markedly reduced at 3 days after the toxin treatment. Thereafter, TH-IR fiber densities showed to progressively recover through the examining period. The number of TH-positive cell bodies in substantia nigra pars compacta were not changed during the recovery period. These results indicate that MPTP-treated mice have a potential for spontaneous regenerative sprouting in nigrostriatal dopaminergic system.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
248
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
660-3
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9703982-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:9703982-Animals,
pubmed-meshheading:9703982-Corpus Striatum,
pubmed-meshheading:9703982-Dopamine,
pubmed-meshheading:9703982-Homovanillic Acid,
pubmed-meshheading:9703982-MPTP Poisoning,
pubmed-meshheading:9703982-Male,
pubmed-meshheading:9703982-Mice,
pubmed-meshheading:9703982-Mice, Inbred C57BL,
pubmed-meshheading:9703982-Nerve Regeneration,
pubmed-meshheading:9703982-Neurons,
pubmed-meshheading:9703982-Substantia Nigra,
pubmed-meshheading:9703982-Time Factors,
pubmed-meshheading:9703982-Tyrosine 3-Monooxygenase
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pubmed:year |
1998
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pubmed:articleTitle |
Spontaneous regeneration of nigrostriatal dopaminergic neurons in MPTP-treated C57BL/6 mice.
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pubmed:affiliation |
Tokushima New Drug Research Institute, Otsuka Pharmaceutical Co., Ltd., Japan.
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pubmed:publicationType |
Journal Article
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