|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1998-8-31
|
|
pubmed:abstractText |
We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70-/- mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4+CD8+ tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1097-2765
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1-8
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:9702186-Animals,
pubmed-meshheading:9702186-Antigens, Nuclear,
pubmed-meshheading:9702186-Cell Differentiation,
pubmed-meshheading:9702186-Cell Line, Transformed,
pubmed-meshheading:9702186-Cell Transformation, Neoplastic,
pubmed-meshheading:9702186-Chromosome Aberrations,
pubmed-meshheading:9702186-Colony-Forming Units Assay,
pubmed-meshheading:9702186-DNA Helicases,
pubmed-meshheading:9702186-DNA Repair,
pubmed-meshheading:9702186-DNA-Activated Protein Kinase,
pubmed-meshheading:9702186-DNA-Binding Proteins,
pubmed-meshheading:9702186-Fibroblasts,
pubmed-meshheading:9702186-Gamma Rays,
pubmed-meshheading:9702186-Genes, Tumor Suppressor,
pubmed-meshheading:9702186-Hirschsprung Disease,
pubmed-meshheading:9702186-Lymphoma, T-Cell,
pubmed-meshheading:9702186-Mice,
pubmed-meshheading:9702186-Mice, Knockout,
pubmed-meshheading:9702186-Mice, SCID,
pubmed-meshheading:9702186-Nuclear Proteins,
pubmed-meshheading:9702186-Phenotype,
pubmed-meshheading:9702186-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9702186-Radiation Tolerance,
pubmed-meshheading:9702186-Sister Chromatid Exchange,
pubmed-meshheading:9702186-T-Lymphocytes,
pubmed-meshheading:9702186-Thymus Neoplasms,
pubmed-meshheading:9702186-Tumor Cells, Cultured
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma.
|
|
pubmed:affiliation |
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. g-li@ski.mskcc.org
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
