rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1998-8-19
|
pubmed:abstractText |
One way to circumvent the need for chronic immunosuppression in solid organ xenografting may be to induce donor-specific tolerance using bone marrow transplantation. If this approach is to succeed in the pig-to-human species combination, pig marrow must be capable of maturing into relevant tolerance-inducing cells and replenishing itself in host human marrow. One possible barrier is adhesion molecule incompatibility. We have studied the compatibility across the pig-human species barrier of two well-characterized ligands known to be important in hematopoiesis, CD44 and very late antigen (VLA)-4.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0041-1337
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
66
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
252-9
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:9701274-Animals,
pubmed-meshheading:9701274-Antigens, CD,
pubmed-meshheading:9701274-Antigens, CD44,
pubmed-meshheading:9701274-Bone Marrow Transplantation,
pubmed-meshheading:9701274-Hematopoiesis,
pubmed-meshheading:9701274-Hematopoietic Stem Cells,
pubmed-meshheading:9701274-Humans,
pubmed-meshheading:9701274-Integrin alpha4,
pubmed-meshheading:9701274-Integrin alpha4beta1,
pubmed-meshheading:9701274-Integrins,
pubmed-meshheading:9701274-Receptors, Lymphocyte Homing,
pubmed-meshheading:9701274-Stromal Cells,
pubmed-meshheading:9701274-Swine,
pubmed-meshheading:9701274-Transplantation, Heterologous
|
pubmed:year |
1998
|
pubmed:articleTitle |
Function of porcine adhesion molecules in a human marrow microenvironment.
|
pubmed:affiliation |
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|