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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0015219,
umls-concept:C0027567,
umls-concept:C0032214,
umls-concept:C0032659,
umls-concept:C0035820,
umls-concept:C0037864,
umls-concept:C0086418,
umls-concept:C0332185,
umls-concept:C0439659,
umls-concept:C0439801,
umls-concept:C0600138,
umls-concept:C1517488,
umls-concept:C1539219,
umls-concept:C1705535,
umls-concept:C2748900
|
| pubmed:issue |
9
|
| pubmed:dateCreated |
1998-10-16
|
| pubmed:abstractText |
The recent transposition to the Y chromosome of the autosomal DAZL1 gene, potentially involved in germ cell development, created a unique opportunity to study the rate of Y chromosome evolution and assess the selective forces that may act upon such genes, and provided a new estimate of the male-to-female mutation rate (alpham). Two different Y-located DAZ sequences were observed in all Old World monkeys, apes and humans. Different DAZ copies originate from independent amplification events in each primate lineage. A comparison of autosomal DAZL1 and Y-linked DAZ intron sequences gave a new figure for male-to-female mutation rates of alpham = 4. It was found that human DAZ exons and introns are evolving at the same rate, implying neutral genetic drift and the absence of any functional selective pressures. We therefore hypothesize that Y-linked DAZ plays little, or a limited, role in human spermatogenesis. The two copies of DAZ in man appear to be due to a relatively recent duplication event (55 000-200 000 years). A worldwide survey of 67 men from five continents representing 19 distinct populations showed that most males have both DAZ variants. This implies a common origin for the Y chromosome consistent with a recent 'out of Africa' origin of the human race.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0964-6906
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1371-7
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9700189-Africa,
pubmed-meshheading:9700189-Animals,
pubmed-meshheading:9700189-Base Sequence,
pubmed-meshheading:9700189-Biological Evolution,
pubmed-meshheading:9700189-Cercopithecidae,
pubmed-meshheading:9700189-Conserved Sequence,
pubmed-meshheading:9700189-DNA Primers,
pubmed-meshheading:9700189-DNA Transposable Elements,
pubmed-meshheading:9700189-Female,
pubmed-meshheading:9700189-Genetic Linkage,
pubmed-meshheading:9700189-Genetic Variation,
pubmed-meshheading:9700189-Humans,
pubmed-meshheading:9700189-Male,
pubmed-meshheading:9700189-Models, Genetic,
pubmed-meshheading:9700189-Multigene Family,
pubmed-meshheading:9700189-Phylogeny,
pubmed-meshheading:9700189-Polymorphism, Genetic,
pubmed-meshheading:9700189-Primates,
pubmed-meshheading:9700189-RNA-Binding Proteins,
pubmed-meshheading:9700189-Spermatogenesis,
pubmed-meshheading:9700189-Y Chromosome
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|