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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-8-31
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pubmed:abstractText |
Munc13-1, a mammalian homolog of C. elegans unc-13p, is thought to be involved in the regulation of synaptic transmission. We now demonstrate that Munc13-1 is a presynaptic high-affinity phorbol ester and diacylglycerol receptor with ligand affinities similar to those of protein kinase C. Munc13-1 associates with the plasma membrane in response to phorbol ester binding and acts as a phorbol ester-dependent enhancer of transmitter release when overexpressed presynaptically in the Xenopus neuromuscular junction. These observations establish Munc13-1 as a novel presynaptic target of the diacylglycerol second messenger pathway that acts in parallel with protein kinase C to regulate neurotransmitter secretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/UNC13B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Unc-13 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Unc13h1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/phorbol ester receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-36
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9697857-Amino Acid Sequence,
pubmed-meshheading:9697857-Animals,
pubmed-meshheading:9697857-Biological Transport,
pubmed-meshheading:9697857-Brain,
pubmed-meshheading:9697857-Caenorhabditis elegans Proteins,
pubmed-meshheading:9697857-Cell Line,
pubmed-meshheading:9697857-Female,
pubmed-meshheading:9697857-Humans,
pubmed-meshheading:9697857-Molecular Sequence Data,
pubmed-meshheading:9697857-Nerve Tissue Proteins,
pubmed-meshheading:9697857-Neuromuscular Junction,
pubmed-meshheading:9697857-Neurotransmitter Agents,
pubmed-meshheading:9697857-Phorbol Esters,
pubmed-meshheading:9697857-Presynaptic Terminals,
pubmed-meshheading:9697857-Protein Kinase C,
pubmed-meshheading:9697857-Rats,
pubmed-meshheading:9697857-Rats, Sprague-Dawley,
pubmed-meshheading:9697857-Receptors, Drug,
pubmed-meshheading:9697857-Synaptic Transmission,
pubmed-meshheading:9697857-Tissue Distribution,
pubmed-meshheading:9697857-Xenopus
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pubmed:year |
1998
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pubmed:articleTitle |
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release.
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pubmed:affiliation |
Max-Planck-Institut für Experimentelle Medizin, Abt. Molekulare Neurobiologie, Göttingen, Bundesrepublik Deutschland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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