Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-9-4
|
| pubmed:abstractText |
The characteristics of sequential human immunodeficiency virus type 1 (HIV-1) isolates from 12 seroconverters among injection drug users selected for either rapid or slow disease progression were evaluated. All 6 patients who developed AIDS within 5 years were initially infected with syncytium-inducing (SI) variants or showed a transition from non-SI-inducing (NSI) to SI variants. Detection of SI variants was associated with rapid decline of both CD8+ and CD4+ T cells. In contrast, the 6 slow progressors carried only NSI variants and maintained stable or increasing CD8+ T cell levels. The SI variants that were associated with initial infection were dual tropic, with efficient replication in primary macrophages and T cell lines. These results suggest that the ability to replicate in macrophages, rather than the SI or NSI phenotype per se, may be an important determinant of HIV-1 transmission and that dual-tropic viruses, when transmitted, may be associated with rapid progression to AIDS.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
178
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
388-96
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9697718-Adult,
pubmed-meshheading:9697718-Amino Acid Sequence,
pubmed-meshheading:9697718-CD4 Lymphocyte Count,
pubmed-meshheading:9697718-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9697718-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9697718-Cell Line,
pubmed-meshheading:9697718-Cells, Cultured,
pubmed-meshheading:9697718-Disease Progression,
pubmed-meshheading:9697718-Female,
pubmed-meshheading:9697718-Genetic Variation,
pubmed-meshheading:9697718-HIV Envelope Protein gp120,
pubmed-meshheading:9697718-HIV Seropositivity,
pubmed-meshheading:9697718-HIV-1,
pubmed-meshheading:9697718-Humans,
pubmed-meshheading:9697718-Male,
pubmed-meshheading:9697718-Molecular Sequence Data,
pubmed-meshheading:9697718-Peptide Fragments,
pubmed-meshheading:9697718-Sequence Homology, Amino Acid,
pubmed-meshheading:9697718-Substance Abuse, Intravenous,
pubmed-meshheading:9697718-T-Lymphocytes,
pubmed-meshheading:9697718-Time Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users.
|
| pubmed:affiliation |
Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. xfyu@jhsph.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|