Linked Life Data

9697059

Source:http://linkedlifedata.com/resource/pubmed/id/9697059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-10-19
pubmed:abstractText
Turbulent shear stresses created by the fluid dynamic characteristics of prosthetic valves cause damage to blood cells. Platelet activation and damage is extensively described and red blood cell hemolysis is reported in a significant number of valve replacements. Most of these studies have evaluated hemolysis in normal red cells and relate to different valves or replacement procedures rather than the red cell. Prehemolytic red cell damage is rarely considered and only few studies describe the effect of valve replacement on patients with red cell disorders. While hemolytic anemia is the ultimate end-point of valve-induced red cell damage, loss of red cells goes hand in hand with the formation of red cell-derived damaged membranes. It can be hypothesized that alterations (in subpopulations) of red cells and generation of red cell remnants due to the increased shear stress could have a profound physiologic effect before hemolytic anemia is apparent. In patients with red cell disorders, alterations in the red cell membrane suggest that red cell damage will be more pronounced after valve replacement. In this review, determinants of normal and abnormal red cell behavior under shear are discussed as well as some of the possible physiologic consequences of the formation of damaged red cell membranes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0966-8519
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Red cell membrane damage.
pubmed:affiliation
Children's Hospital Oakland Research Institute, Oakland, California 94609, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review