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pubmed-article:9695716pubmed:abstractTextDynorphin A(1-13) is a fragment of the endogenous opioid neuropeptide dynorphin A. Previous research suggested that intravenously administered dynorphin A(1-13) has the ability to modulate morphine-induced analgesia. We designed this study to characterize the disposition of intravenous dynorphin immunoreactivity in humans and to determine whether concomitant long-term opioid therapy influenced the pharmacokinetics or side-effects profile of dynorphin A(1-13).lld:pubmed
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pubmed-article:9695716pubmed:articleTitlePharmacokinetics of intravenous dynorphin A(1-13) in opioid-naive and opioid-treated human volunteers.lld:pubmed
pubmed-article:9695716pubmed:affiliationDepartmento de Anestesiologia, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain.lld:pubmed
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