Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0017262,
umls-concept:C0021757,
umls-concept:C0023467,
umls-concept:C0079460,
umls-concept:C0185117,
umls-concept:C0205214,
umls-concept:C0330390,
umls-concept:C0332281,
umls-concept:C0337112,
umls-concept:C0530698,
umls-concept:C1145670,
umls-concept:C1524075,
umls-concept:C2911684
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-9-10
|
| pubmed:abstractText |
Deficiency of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin-3 (IL-3)/IL-5 receptors common beta chain (betac) is a cause of fatal respiratory failure. betac deficiency manifests as pulmonary alveolar proteinosis (PAP). PAP has heterogenous etiologies that may be genetic or aquired. Some cases of PAP have been reported to be associated with hematologic malignancies such as acute myeloid leukemia (AML). In mice, the PAP phenotype was generated by targeted deletion of the gene for betac and can be treated by transplantation of wild-type bone marrow into betac -/- mice. Thus, our findings in betac -/- mice provide evidence for a causal relationship between the lung disease and the hematopoietic system. We describe here expression defects of betac or betac plus GM-CSF receptor alpha chain (GM-CSFR alpha) in 3 pediatric patients with AML and PAP symptoms. All of the patients' leukemic cells failed to express normal levels of betac. The leukemic cells of patients no. 2 and 3 additionally lacked the expression of GM-CSFR alpha, as shown by flow cytometry. Strikingly reduced or absent function of betac was demonstrated in clonogenic progenitor assays with absent colony-forming unit (CFU) growth after GM-CSF or IL-3 stimulation. The response to growth factors acting via a growth factor receptor distinct from the GM-CSF/IL-3/IL-5 system (recombinant human granulocyte colony-stimulating factor [rhG-CSF]) was normal. After antileukemic treatment, the pulmonary symptoms resolved and betac or betac plus GM-CSFR alpha expression was normal. Our findings provide evidence that a defect in the expression of betac or betac plus GM-CSFR alpha on AML blasts can be associated with respiratory failure in patients with AML.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactants,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-5
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 by The American Society of Hematology.
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1097-103
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9694696-Acute Disease,
pubmed-meshheading:9694696-Adult,
pubmed-meshheading:9694696-Animals,
pubmed-meshheading:9694696-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9694696-Bone Marrow Transplantation,
pubmed-meshheading:9694696-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:9694696-Cell Lineage,
pubmed-meshheading:9694696-Child,
pubmed-meshheading:9694696-Fatal Outcome,
pubmed-meshheading:9694696-Female,
pubmed-meshheading:9694696-Gene Expression Regulation, Leukemic,
pubmed-meshheading:9694696-Humans,
pubmed-meshheading:9694696-Infant,
pubmed-meshheading:9694696-Leukemia, Monocytic, Acute,
pubmed-meshheading:9694696-Leukemia, Myeloid,
pubmed-meshheading:9694696-Leukemia, Myelomonocytic, Acute,
pubmed-meshheading:9694696-Macrophages, Alveolar,
pubmed-meshheading:9694696-Male,
pubmed-meshheading:9694696-Mice,
pubmed-meshheading:9694696-Mice, Knockout,
pubmed-meshheading:9694696-Pulmonary Alveolar Proteinosis,
pubmed-meshheading:9694696-Pulmonary Surfactants,
pubmed-meshheading:9694696-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9694696-Receptors, Interleukin,
pubmed-meshheading:9694696-Receptors, Interleukin-3,
pubmed-meshheading:9694696-Receptors, Interleukin-5,
pubmed-meshheading:9694696-Respiratory Insufficiency
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure.
|
| pubmed:affiliation |
Department of Pediatric Hematology/Oncology, Children's Hospital Medical Center, Heinrich-Heine-University, Düsseldorf, Germany. dirksen@un-duesseldorf.de
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|