Linked Life Data

9694559

Source:http://linkedlifedata.com/resource/pubmed/id/9694559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6-7
pubmed:dateCreated
1998-10-13
pubmed:abstractText
There is evidence to suggest that the cells of the vascular endothelium secrete factors, including endothelin-1, nitric oxide, adrenomedullin and PAMP which have a role in regulating adrenal function. There is strong evidence from many studies that each of these factors is able to affect aldosterone secretion, with much less evidence relating to glucocorticoid secretion. The recent evidence suggests that both adrenomedullin and PAMP, like endothelin-1, stimulate aldosterone secretion. The controversies surrounding this issue are discussed. What emerges most strongly from the literature, however, is the evidence that, in addition to being secreted by the vascular endothelium of the adrenal, the peptides endothelin-1 and adrenomedullin are produced within the zona glomerulosa cells themselves, suggesting an autocrine as well as a paracrine role in the regulation of zona glomerulosa function and aldosterone secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
334-40
pubmed:dateRevised
2009-2-19
pubmed:meshHeading
pubmed:articleTitle
The role of endothelial cell products in the regulation of adrenocortical function: actions of endothelin, nitric oxide, adrenomedullin and PAMP.
pubmed:affiliation
Department of Biochemistry, Faculty of Basic Medical Sciences, St Bartholomew's School of Medicine, Queen Mary and Westfield College, London, UK.
pubmed:publicationType
Journal Article, Review