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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-10-14
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pubmed:abstractText |
Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Gdnf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2365-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9694229-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:9694229-Aging,
pubmed-meshheading:9694229-Animals,
pubmed-meshheading:9694229-Antiparkinson Agents,
pubmed-meshheading:9694229-Dopamine,
pubmed-meshheading:9694229-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:9694229-Image Processing, Computer-Assisted,
pubmed-meshheading:9694229-Immunohistochemistry,
pubmed-meshheading:9694229-Male,
pubmed-meshheading:9694229-Mice,
pubmed-meshheading:9694229-Mice, Inbred C57BL,
pubmed-meshheading:9694229-Neostriatum,
pubmed-meshheading:9694229-Nerve Growth Factors,
pubmed-meshheading:9694229-Nerve Tissue Proteins,
pubmed-meshheading:9694229-Neuroprotective Agents,
pubmed-meshheading:9694229-Parkinson Disease, Secondary,
pubmed-meshheading:9694229-Substantia Nigra,
pubmed-meshheading:9694229-Tyrosine 3-Monooxygenase
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pubmed:year |
1998
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pubmed:articleTitle |
GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice.
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pubmed:affiliation |
Department of Neurological Surgery, Okayama University Medical School, Japan.
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pubmed:publicationType |
Journal Article
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