| pubmed-article:9693141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C0460005 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C0039259 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C1160070 | lld:lifeskim |
| pubmed-article:9693141 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9693141 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:9693141 | pubmed:dateCreated | 1998-10-14 | lld:pubmed |
| pubmed-article:9693141 | pubmed:abstractText | Inhibition of fibroblast growth factor (FGF) signaling prevents trunk and tail formation in Xenopus and zebrafish embryos. While the T-box transcription factor Brachyury (called No Tail in zebrafish) is a key mediator of FGF signaling in the notochord and tail, the pathways activated by FGF in non-notochordal trunk mesoderm have been uncertain. Previous studies have shown that the spadetail gene is required for non-notochordal trunk mesoderm formation; spadetail mutant embryos have major trunk mesoderm deficiencies, but relatively normal tail and notochord development. We demonstrate here that spadetail encodes a T-box transcription factor with homologues in Xenopus and chick. Spadetail is likely to be a key mediator of FGF signaling in trunk non-notochordal mesoderm, since spadetail expression is regulated by FGF signaling. Trunk and tail development are therefore dependent upon the complementary actions of two T-box genes, spadetail and no tail. We show that the regulatory hierarchy among spadetail, no tail and a third T-box gene, tbx6, are substantially different during trunk and tail mesoderm formation, and propose a genetic model that accounts for the regional phenotypes of spadetail and no tail mutants. | lld:pubmed |
| pubmed-article:9693141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9693141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9693141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9693141 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9693141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9693141 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9693141 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:9693141 | pubmed:author | pubmed-author:KimmelC BCB | lld:pubmed |
| pubmed-article:9693141 | pubmed:author | pubmed-author:KimelmanDD | lld:pubmed |
| pubmed-article:9693141 | pubmed:author | pubmed-author:GriffinK JKJ | lld:pubmed |
| pubmed-article:9693141 | pubmed:author | pubmed-author:AmacherS LSL | lld:pubmed |
| pubmed-article:9693141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9693141 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:9693141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9693141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9693141 | pubmed:pagination | 3379-88 | lld:pubmed |
| pubmed-article:9693141 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9693141 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9693141 | pubmed:articleTitle | Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. | lld:pubmed |
| pubmed-article:9693141 | pubmed:affiliation | Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98195-7350, USA. | lld:pubmed |
| pubmed-article:9693141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9693141 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9693141 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9693141 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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