Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-10-8
pubmed:abstractText
Transcription factors belonging to the CCAAT-enhancer binding protein (C/EBP) family have been implicated in the activation of gene expression in the mammary gland during lactation. We have therefore investigated the detailed expression profile of the C/EBP family during lactation and involution of the mouse mammary gland. The expression of C/EBPbeta and C/EBPdelta mRNA was low during lactation, increased dramatically at the beginning of involution and remained constant thereafter. In contrast, C/EBPalpha mRNA expression was relatively high during the early stages of lactation, declined to low levels during the late stages of lactation and at the start of involution, and increased again during involution. Electrophoretic mobility-shift assays showed a close correlation between the expression of the C/EBP genes and the functional C/EBP DNA-binding activity and, additionally, demonstrated the participation of heterodimers, formed from among the three proteins, in DNA-protein interactions. The DNA-binding activity of the activator protein 1 (AP1) family of transcription factors was also induced during involution. These results therefore point to potentially important regulatory roles for both the C/EBP and the AP1 family during lactation and involution of the mammary gland.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-1331936, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-1512297, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-1638991, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-17180107, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-1840554, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-1934061, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-2020548, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-2171780, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-7491114, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-7531665, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-7574486, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-7629103, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-7680115, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-7906646, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8134124, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8135737, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8185814, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8294101, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8343535, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8367486, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8530141, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8557032, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8565829, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-8906870, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-9045647, http://linkedlifedata.com/resource/pubmed/commentcorrection/9693121-9428809
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
334 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution.
pubmed:affiliation
School of Molecular and Medical Biosciences, University of Wales Cardiff, P.O. Box 911, Cardiff CF1 3US, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't