Linked Life Data

9692880

Source:http://linkedlifedata.com/resource/pubmed/id/9692880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1998-8-13
pubmed:abstractText
Incomplete allelic exclusion of TCRa gene rearrangement permits the generation of dual Valpha T cells, though the issues of their frequency and whether both alphabeta pairs participate in thymic selection have not been resolved. Both questions have been investigated using lymphocytes from mice hemizygous at the TCRa locus and consequently unable to express two rearranged TCRa genes, as background controls. The data presented show that both the frequency of dual Valpha T cells and the relative expression levels of co-expressed Valpha chains are variable and are determined by thymic selection. Possession of a Valpha chain which is inefficiently positively selected appears to increase the likelihood that a second Valpha chain will be co-expressed, whilst the relative cell surface levels of a given pair of Valpha chains differ between CD4 and CD8 subsets. Further, for some but not all Valpha pairs, dual Valpha T cells appear to express elevated levels of surface TCR. Finally, contrary to previous claims, dual Valpha T cells do not appear to be relatively frequent amongst immature thymocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2115-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Selection of dual Valpha T cells.
pubmed:affiliation
Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, GB. jielliot@rpms.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't