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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-8-13
|
| pubmed:abstractText |
Rubella infections, notified by general practitioners on the basis of a clinical diagnosis, were investigated by testing blood and saliva samples for specific IgM. Overall 52 (29%) of 178 cases with appropriately timed blood specimens were confirmed as recent rubella by IgM serology. Only 2 (3%) of 74 cases in children under 5 years were confirmed compared to 50 (48%) of 104 cases in older children and adults. The confirmation rate was lower (6%) in those with documented vaccination history than in those without (42%). The specificity of saliva rubella IgM testing compared to testing corresponding blood samples was 99%. The overall sensitivity of saliva rubella IgM testing was 81%. This rose to 90% if results from inappropriately timed specimens and specimens taking more than 1 week to reach the laboratory were excluded. A corresponding saliva rubella IgG test was 98% sensitive and 100% specific. Of 126 rubella IgM negative cases, 25 (20%) were positive for parvovirus B19 IgM. This study confirmed that rubella surveillance based on clinical reports is not specific. It also demonstrated that saliva samples, if taken 7-42 days after onset of illness and transported rapidly to the laboratory, are a feasible alternative to blood samples for rubella surveillance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0950-2688
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
315-9
|
| pubmed:dateRevised |
2010-3-3
|
| pubmed:meshHeading |
pubmed-meshheading:9692610-Adolescent,
pubmed-meshheading:9692610-Adult,
pubmed-meshheading:9692610-Aged,
pubmed-meshheading:9692610-Antibodies, Viral,
pubmed-meshheading:9692610-Child,
pubmed-meshheading:9692610-Child, Preschool,
pubmed-meshheading:9692610-Humans,
pubmed-meshheading:9692610-Immunoglobulin G,
pubmed-meshheading:9692610-Immunoglobulin M,
pubmed-meshheading:9692610-Infant,
pubmed-meshheading:9692610-Middle Aged,
pubmed-meshheading:9692610-Rubella,
pubmed-meshheading:9692610-Saliva,
pubmed-meshheading:9692610-Sensitivity and Specificity
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Salivary diagnosis of rubella: a study of notified cases in the United Kingdom, 1991-4.
|
| pubmed:affiliation |
Immunisation Division, Communicable Disease Surveillance Centre.
|
| pubmed:publicationType |
Journal Article
|