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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-8-14
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pubmed:abstractText |
Organ preservation injury is associated with endothelial cell damage, destabilization of mitochondrial and cell membranes, and the release of proteolytic enzymes. In addition to its well-known clinical effect of reducing perioperative blood loss, aprotinin has antiproteolytic and membrane-stabilizing properties. We hypothesized that adding aprotinin to Euro-Collins (EC) and University of Wisconsin (UW) solutions would decrease preservation injury in cultured endothelial cells and a whole organ rat lung model.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Allopurinol,
http://linkedlifedata.com/resource/pubmed/chemical/Aprotinin,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Euro-Collins' solution,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Hemostatics,
http://linkedlifedata.com/resource/pubmed/chemical/Hypertonic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Organ Preservation Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Raffinose,
http://linkedlifedata.com/resource/pubmed/chemical/University of...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-4975
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-30
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9692469-Adenosine,
pubmed-meshheading:9692469-Allopurinol,
pubmed-meshheading:9692469-Animals,
pubmed-meshheading:9692469-Aprotinin,
pubmed-meshheading:9692469-Capillaries,
pubmed-meshheading:9692469-Cattle,
pubmed-meshheading:9692469-Cell Membrane,
pubmed-meshheading:9692469-Cell Survival,
pubmed-meshheading:9692469-Cells, Cultured,
pubmed-meshheading:9692469-Cryopreservation,
pubmed-meshheading:9692469-Endopeptidases,
pubmed-meshheading:9692469-Endothelium, Vascular,
pubmed-meshheading:9692469-Glutathione,
pubmed-meshheading:9692469-Hemostatics,
pubmed-meshheading:9692469-Hypertonic Solutions,
pubmed-meshheading:9692469-Insulin,
pubmed-meshheading:9692469-Lung Compliance,
pubmed-meshheading:9692469-Lung Diseases,
pubmed-meshheading:9692469-Lung Transplantation,
pubmed-meshheading:9692469-Male,
pubmed-meshheading:9692469-Mitochondria,
pubmed-meshheading:9692469-Organ Preservation Solutions,
pubmed-meshheading:9692469-Oxygen,
pubmed-meshheading:9692469-Oxygen Consumption,
pubmed-meshheading:9692469-Protease Inhibitors,
pubmed-meshheading:9692469-Raffinose,
pubmed-meshheading:9692469-Rats,
pubmed-meshheading:9692469-Rats, Wistar,
pubmed-meshheading:9692469-Reperfusion Injury,
pubmed-meshheading:9692469-Ventilation-Perfusion Ratio
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pubmed:year |
1998
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pubmed:articleTitle |
Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury.
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pubmed:affiliation |
Department of Surgery, University of Southern California School of Medicine and Childrens Hospital Los Angele, 90033, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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