rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
1998-8-6
|
pubmed:abstractText |
Bisphosphonates are effective against the increased bone resorption caused by certain diseases because they inhibit the activity of osteoclasts. In patients who have breast cancer and metastatic bone disease, the bisphosphonate clodronate (clodronic acid) reduces the frequency of skeletal complications. Experiments in animals and preliminary clinical observations indicate that early clodronate therapy reduces the incidence of new bony metastases in breast cancer. We investigated the effects of clodronate on the incidence and extent of new metastases in patients with breast cancer.
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pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0028-4793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
339
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
357-63
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9691101-Adult,
pubmed-meshheading:9691101-Aged,
pubmed-meshheading:9691101-Bone Neoplasms,
pubmed-meshheading:9691101-Breast Neoplasms,
pubmed-meshheading:9691101-Chemotherapy, Adjuvant,
pubmed-meshheading:9691101-Clodronic Acid,
pubmed-meshheading:9691101-Female,
pubmed-meshheading:9691101-Humans,
pubmed-meshheading:9691101-Incidence,
pubmed-meshheading:9691101-Middle Aged,
pubmed-meshheading:9691101-Neoplasm Metastasis,
pubmed-meshheading:9691101-Prospective Studies,
pubmed-meshheading:9691101-Survival Analysis
|
pubmed:year |
1998
|
pubmed:articleTitle |
Reduction in new metastases in breast cancer with adjuvant clodronate treatment.
|
pubmed:affiliation |
Department of Obstetrics and Gynecology, University of Heidelberg, Germany.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|