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pubmed-article:9690201pubmed:abstractTextWe previously showed that chronic administration of an angiotensin converting enzyme (ACE) inhibitor to rats with passive Heymann nephritis (PHN), a model of membranous nephropathy with proteinuria and increased renal synthesis of endothelin-1 (ET-1), reduces urinary proteins and partially limits the exaggerated ET-1 renal synthesis. Here we compared the effect of an ETA receptor antagonist and an ACE-inhibitor given as single therapies with a combination of the two drugs in uninephrectomized PHN rats.lld:pubmed
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pubmed-article:9690201pubmed:articleTitleRenoprotective effect of contemporary blocking of angiotensin II and endothelin-1 in rats with membranous nephropathy.lld:pubmed
pubmed-article:9690201pubmed:affiliationMario Negri Institute for Pharmacological Research, Ospedali Riuniti di Bergamo, Italy.lld:pubmed
pubmed-article:9690201pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9690201pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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