|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1998-10-15
|
|
pubmed:abstractText |
We previously showed that chronic administration of an angiotensin converting enzyme (ACE) inhibitor to rats with passive Heymann nephritis (PHN), a model of membranous nephropathy with proteinuria and increased renal synthesis of endothelin-1 (ET-1), reduces urinary proteins and partially limits the exaggerated ET-1 renal synthesis. Here we compared the effect of an ETA receptor antagonist and an ACE-inhibitor given as single therapies with a combination of the two drugs in uninephrectomized PHN rats.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0085-2538
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
353-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9690201-Angiotensin II,
pubmed-meshheading:9690201-Animals,
pubmed-meshheading:9690201-Blood Pressure,
pubmed-meshheading:9690201-Endothelin-1,
pubmed-meshheading:9690201-Glomerulonephritis,
pubmed-meshheading:9690201-Indoles,
pubmed-meshheading:9690201-Kidney,
pubmed-meshheading:9690201-Male,
pubmed-meshheading:9690201-Phenylpropionates,
pubmed-meshheading:9690201-Proteinuria,
pubmed-meshheading:9690201-Pyrimidines,
pubmed-meshheading:9690201-Rats,
pubmed-meshheading:9690201-Rats, Sprague-Dawley
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Renoprotective effect of contemporary blocking of angiotensin II and endothelin-1 in rats with membranous nephropathy.
|
|
pubmed:affiliation |
Mario Negri Institute for Pharmacological Research, Ospedali Riuniti di Bergamo, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
