| pubmed-article:9688731 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0005768 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0019944 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0232338 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C0682132 | lld:lifeskim |
| pubmed-article:9688731 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:9688731 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9688731 | pubmed:dateCreated | 1998-9-3 | lld:pubmed |
| pubmed-article:9688731 | pubmed:abstractText | We investigated regional differences of in vitro responses of pulmonary arteries (6-mm OD) from the dorsocaudal (top) and cranioventral (bottom) lung regions to endothelium-dependent vasodilators (methacholine, bradykinin, and calcium ionophore A-23187). Methacholine relaxed endothelium-intact top vessels; however, in bottom vessels, a small relaxation preceded a profound contraction. In top vessels, removal of endothelial cells converted relaxation to contraction, and in bottom vessels it abolished relaxation and enhanced contraction. Bradykinin and A-23187 were more potent and caused greater endothelium-mediated relaxation in top than in bottom arteries. The endothelium-independent vasodilator sodium nitroprusside caused similar relaxations in all rings. Nomega-nitro-L-arginine and NG-monomethyl-L-arginine and methylene blue abolished relaxation of top and bottom arteries to methacholine; meclofenamate had little effect. We conclude that regional differences in endothelium-mediated relaxation are caused by differences in the magnitude of the endothelial release of nitric oxide. Similar differences in endothelium-dependent flow-mediated vasodilation and endothelial nitric oxide release may result in preferential perfusion of caudodorsal lung regions. | lld:pubmed |
| pubmed-article:9688731 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9688731 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9688731 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9688731 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9688731 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:9688731 | pubmed:author | pubmed-author:RobinsonN ENE | lld:pubmed |
| pubmed-article:9688731 | pubmed:author | pubmed-author:DerksenF JFJ | lld:pubmed |
| pubmed-article:9688731 | pubmed:author | pubmed-author:PelletierNN | lld:pubmed |
| pubmed-article:9688731 | pubmed:author | pubmed-author:KaiserLL | lld:pubmed |
| pubmed-article:9688731 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9688731 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:9688731 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9688731 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9688731 | pubmed:pagination | 537-42 | lld:pubmed |
| pubmed-article:9688731 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:9688731 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9688731 | pubmed:articleTitle | Regional differences in endothelial function in horse lungs: possible role in blood flow distribution? | lld:pubmed |
| pubmed-article:9688731 | pubmed:affiliation | Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA. | lld:pubmed |
| pubmed-article:9688731 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9688731 | lld:pubmed |
