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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-9-3
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pubmed:abstractText |
We investigated regional differences of in vitro responses of pulmonary arteries (6-mm OD) from the dorsocaudal (top) and cranioventral (bottom) lung regions to endothelium-dependent vasodilators (methacholine, bradykinin, and calcium ionophore A-23187). Methacholine relaxed endothelium-intact top vessels; however, in bottom vessels, a small relaxation preceded a profound contraction. In top vessels, removal of endothelial cells converted relaxation to contraction, and in bottom vessels it abolished relaxation and enhanced contraction. Bradykinin and A-23187 were more potent and caused greater endothelium-mediated relaxation in top than in bottom arteries. The endothelium-independent vasodilator sodium nitroprusside caused similar relaxations in all rings. Nomega-nitro-L-arginine and NG-monomethyl-L-arginine and methylene blue abolished relaxation of top and bottom arteries to methacholine; meclofenamate had little effect. We conclude that regional differences in endothelium-mediated relaxation are caused by differences in the magnitude of the endothelial release of nitric oxide. Similar differences in endothelium-dependent flow-mediated vasodilation and endothelial nitric oxide release may result in preferential perfusion of caudodorsal lung regions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcimycin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ionophores,
http://linkedlifedata.com/resource/pubmed/chemical/Methacholine Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
8750-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
537-42
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9688731-Animals,
pubmed-meshheading:9688731-Bradykinin,
pubmed-meshheading:9688731-Calcimycin,
pubmed-meshheading:9688731-Endothelium, Vascular,
pubmed-meshheading:9688731-Enzyme Inhibitors,
pubmed-meshheading:9688731-Horses,
pubmed-meshheading:9688731-Ionophores,
pubmed-meshheading:9688731-Lung,
pubmed-meshheading:9688731-Methacholine Chloride,
pubmed-meshheading:9688731-Muscarinic Agonists,
pubmed-meshheading:9688731-Nitric Oxide,
pubmed-meshheading:9688731-Nitric Oxide Synthase,
pubmed-meshheading:9688731-Nitroarginine,
pubmed-meshheading:9688731-Nitroprusside,
pubmed-meshheading:9688731-Potassium Chloride,
pubmed-meshheading:9688731-Pulmonary Circulation,
pubmed-meshheading:9688731-Vasodilation,
pubmed-meshheading:9688731-Vasodilator Agents
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pubmed:year |
1998
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pubmed:articleTitle |
Regional differences in endothelial function in horse lungs: possible role in blood flow distribution?
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pubmed:affiliation |
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA.
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pubmed:publicationType |
Journal Article
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