Linked Life Data

9688689

Source:http://linkedlifedata.com/resource/pubmed/id/9688689

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1998-9-16
pubmed:abstractText
Systemically administered alpha-melanocyte-stimulating hormone (alpha-MSH) inhibits endotoxin (lipopolysaccharide; LPS)- or interleukin (IL)-1-induced fever and adrenocortical activation, but the sites of these actions and the mechanisms involved are unknown. The aims of this study were, first, to determine whether melanocortin receptors (MCR) located within the central nervous system mediate the suppressive effects of peripherally administered alpha-MSH on LPS-induced fever and activation of the pituitary-adrenal axis and, second, to determine whether systemic alpha-MSH suppresses the LPS-induced rise in plasma IL-6 levels, potentially contributing to its antipyretic effect. Male rats received Escherichia coli LPS (25 microg/kg ip). Core body temperatures (Tb) were determined hourly by radiotelemetry (0-8 h), and blood was withdrawn via venous catheters for plasma hormone immunoassays (0-2 h) and IL-6 bioassay (0-8 h). alpha-MSH (100 microg/kg ip) completely prevented the onset of LPS-induced fever during the first 3-4 h after LPS and suppressed fever throughout the next 4 h but did not affect Tb in afebrile rats treated with intraperitoneal saline rather than LPS. Intraperitoneal alpha-MSH also suppressed the LPS-induced rise in plasma IL-6, ACTH, and corticosterone (CS) levels. Intracerebroventricular injection of SHU-9119, a potent melanocortin-4 receptor (MC4-R)/MC3-R antagonist, completely blocked the antipyretic effect of intraperitoneal alpha-MSH during the first 4 h after LPS but had no effect on alpha-MSH-induced suppression of LPS-stimulated plasma IL-6 and CS levels. Taken together, the results indicate that the antipyretic effect of peripherally administered alpha-MSH during the early phase of fever is mediated by MCR within the brain. In contrast, the inhibition of LPS-induced increases in plasma CS and IL-6 levels by intraperitoneal alpha-MSH appears to be mediated by a different mechanism(s), and these effects do not contribute to its antipyretic action.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
275
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R524-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9688689-Adrenocorticotropic Hormone, pubmed-meshheading:9688689-Animals, pubmed-meshheading:9688689-Body Temperature, pubmed-meshheading:9688689-Cerebral Ventricles, pubmed-meshheading:9688689-Corticosterone, pubmed-meshheading:9688689-Escherichia coli, pubmed-meshheading:9688689-Fever, pubmed-meshheading:9688689-Infusions, Parenteral, pubmed-meshheading:9688689-Injections, Intraperitoneal, pubmed-meshheading:9688689-Injections, Intraventricular, pubmed-meshheading:9688689-Interleukin-6, pubmed-meshheading:9688689-Lipopolysaccharides, pubmed-meshheading:9688689-Male, pubmed-meshheading:9688689-Melanocyte-Stimulating Hormones, pubmed-meshheading:9688689-Rats, pubmed-meshheading:9688689-Rats, Sprague-Dawley, pubmed-meshheading:9688689-Receptor, Melanocortin, Type 4, pubmed-meshheading:9688689-Receptors, Corticotropin, pubmed-meshheading:9688689-Receptors, Peptide, pubmed-meshheading:9688689-alpha-MSH
pubmed:year
1998
pubmed:articleTitle
Systemic alpha-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release.
pubmed:affiliation
Department of Medicine and the Tupper Research Institute, Tufts University School of Medicine and New England Medical Center Hospitals, Boston, Massachusetts 02111, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.