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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1998-8-24
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pubmed:abstractText |
An increased proportion of citrullinated MBP (MBP-C8) occurs in the brains of multiple sclerosis (MS) patients. In this study, MBP-C8 from guinea pig (GP) brains was isolated and found encephalitogenic in Lewis rats upon immunization. An encephalitogenic T cell line selected with MBP-C8 preferentially reacted with MBP-C8 over unmodified MBP. This T cell line responded weakly to the dominant encephalitogenic epitope, GP-MBP peptide 70-88, and did not display restricted TCR beta-chain usage (such as Vbeta88.2). The distinctive features of MBP-C8 were also demonstrated by its ability to reinduce active EAE in 70% of rats which had recovered from unmodified MBP induced EAE. These findings raise the possibility that citrullinated MBP may elicit a different pathogenic T cell repertoire for the recurrent phases of inflammatory demyelination.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9688320-Animals,
pubmed-meshheading:9688320-Antibody Formation,
pubmed-meshheading:9688320-Citrulline,
pubmed-meshheading:9688320-Disease Susceptibility,
pubmed-meshheading:9688320-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:9688320-Epitopes,
pubmed-meshheading:9688320-Female,
pubmed-meshheading:9688320-Guinea Pigs,
pubmed-meshheading:9688320-Immunochemistry,
pubmed-meshheading:9688320-Myelin Basic Proteins,
pubmed-meshheading:9688320-Peptide Fragments,
pubmed-meshheading:9688320-Polymerase Chain Reaction,
pubmed-meshheading:9688320-Rats,
pubmed-meshheading:9688320-Rats, Inbred Lew,
pubmed-meshheading:9688320-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9688320-T-Lymphocytes,
pubmed-meshheading:9688320-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Citrullinated myelin basic protein induces experimental autoimmune encephalomyelitis in Lewis rats through a diverse T cell repertoire.
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pubmed:affiliation |
Department of Neurology, University of Alabama at Birmingham, 35294-0007, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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