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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-8-12
|
| pubmed:abstractText |
Monocyte-macrophage activation by IFN-gamma is characterized by a pronounced increase of high affinity Fc receptors for IgG (Fc gamma RI), capable of triggering respiratory burst, phagocytosis, Ab-dependent cytotoxicity, and release of proinflammatory cytokines. In view of the antagonism of IFN-beta on IFN-gamma action, of interest in the chronic inflammatory disorder multiple sclerosis, we examined the possible effect of IFN-beta on IFN-gamma induction of Fc gamma RI gene expression. We found that IFN-beta significantly down-regulated IFN-gamma-induced Fc gamma RI surface expression in peripheral blood monocytes from healthy donors, in a dose- and time-dependent manner. This down-regulation of Fc gamma RI surface levels did not correspond to a decrease in Fc gamma RI mRNA, suggesting a posttranscriptional effect of IFN-beta. Down-regulation of Fc gamma RI surface expression correlated with diminished cellular signaling through Fc gamma RI, since the IFN-gamma-induced increase in Fc gamma receptor-triggered respiratory burst was nearly completely abrogated by simultaneous addition of IFN-beta. Finally, the same antagonism between both IFNs on Fc gamma RI surface expression was observed in peripheral blood monocytes derived from multiple sclerosis patients; inhibition by IFN-beta was even increased (82+/-11%), as compared with healthy controls (67+/-4%). These results may partially help explain the beneficial effect of IFN-beta in multiple sclerosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
161
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1568-74
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9686625-Adult,
pubmed-meshheading:9686625-Cells, Cultured,
pubmed-meshheading:9686625-Cytokines,
pubmed-meshheading:9686625-Dose-Response Relationship, Immunologic,
pubmed-meshheading:9686625-Down-Regulation,
pubmed-meshheading:9686625-Female,
pubmed-meshheading:9686625-Humans,
pubmed-meshheading:9686625-Interferon-beta,
pubmed-meshheading:9686625-Interferon-gamma,
pubmed-meshheading:9686625-Intracellular Fluid,
pubmed-meshheading:9686625-Male,
pubmed-meshheading:9686625-Membrane Proteins,
pubmed-meshheading:9686625-Middle Aged,
pubmed-meshheading:9686625-Monocytes,
pubmed-meshheading:9686625-Multiple Sclerosis,
pubmed-meshheading:9686625-RNA, Messenger,
pubmed-meshheading:9686625-Receptors, IgG,
pubmed-meshheading:9686625-Respiratory Burst,
pubmed-meshheading:9686625-Time Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients.
|
| pubmed:affiliation |
Unité 365, Institut National de la Santé et de la Recherche Médicale, Institut Curie, Paris, France. u365@curie.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|