Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-8-12
|
| pubmed:abstractText |
Collagen-induced arthritis (CIA) is an arthritic model that was developed after immunization with type II collagen (CII). Apparently, contradictory results have been reported regarding the role of IFN-gamma in the development of CIA. Therefore, we employed IFN-gamma R-deficient mice to study the role of IFN-gamma. To introduce the CIA susceptibility gene (H-2q), IFN-gamma R-deficient (H-2b/b/IFN-gamma R-/-) mice were mated with DBA/1 (H-2q/q/IFN-gamma R+/+) mice; next, the F1 mice were interbred to yield F2 offspring bearing different combinations of H-2 (H-2q/q, H-2q/b, and H-2b/b) and IFN-gamma R (IFN-gamma R+/+, IFN-gamma R+/-, and IFN-gamma R-/-) genes. Although the H-2q allele appeared to confer susceptibility to CIA, mice that were homozygous for the IFN-gamma R mutation showed a substantially decreased incidence and severity of CIA. The CII-specific IgG levels of serum samples, which are known to be involved in the development of CIA, were remarkably reduced in IFN-gamma R-/- mice. Furthermore, the anti-CII IgG2a levels controlled by IFN-gamma R were significantly reduced in IFN-gamma R-/- F2 mice compared with those seen in IFN-gamma R+/+ and IFN-gamma R+/- mice, although the levels of all IgG subclass Abs examined were lower in IFN-gamma R-/- mice than in IFN-gamma R+/+ mice. No clear evidence of the imbalance of Th1/Th2 cytokines was observed in CII-immunized, IFN-gamma R-deficient mice. Taken together, these results suggest that IFN-gamma exacerbates CIA by affecting, at least, levels of CII-specific IgG Ab rather than the imbalance of Th1/Th2 cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
161
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1542-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9686622-Animals,
pubmed-meshheading:9686622-Arthritis, Experimental,
pubmed-meshheading:9686622-Collagen,
pubmed-meshheading:9686622-Crosses, Genetic,
pubmed-meshheading:9686622-Cytokines,
pubmed-meshheading:9686622-Disease Susceptibility,
pubmed-meshheading:9686622-Gene Deletion,
pubmed-meshheading:9686622-Heterozygote,
pubmed-meshheading:9686622-Homozygote,
pubmed-meshheading:9686622-Immunoglobulin G,
pubmed-meshheading:9686622-Incidence,
pubmed-meshheading:9686622-Interferon-gamma,
pubmed-meshheading:9686622-Mice,
pubmed-meshheading:9686622-Mice, Inbred DBA,
pubmed-meshheading:9686622-Mice, Inbred Strains,
pubmed-meshheading:9686622-Mice, Knockout,
pubmed-meshheading:9686622-Receptors, Interferon,
pubmed-meshheading:9686622-Spleen
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor.
|
| pubmed:affiliation |
Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article
|