Linked Life Data

9686306

Source:http://linkedlifedata.com/resource/pubmed/id/9686306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-10-22
pubmed:abstractText
An extracted Bence Jones lambda protein from a Japanese patient with myeloma-associated Fanconi syndrome was found to contain 5 components, including the dimer and the monomer of the entire light-chain, the dimer and the monomer of the constant domain, and monomer of the variable domain. The entire amino acid sequence of this lambda chain was completed. The protein, containing 5 components, was injected intraperitoneally in C3H mice, 20 mg for 13 days and 200 mg for 3 days. Both groups of C3H mice showed a renal proximal tubular deposition of variable domain fragment of the Bence Jones protein by immunoperoxidase staining. Other control Bence Jones proteins of the lambda type and serum albumin were negative in terms of deposition in the epithelial tubular cells. It is also shown that the proximal tubules of the biopsied kidney from the patient had a deposition of variable domain fragment of Bence Jones protein. Thus, the myeloma-associated Fanconi syndrome could be included in the spectrum of light-chain associated disease or monoclonal Ig deposition disease. This is the first case of lambda type Bence Jones protein with a complete amino acid sequence analysis found in Fanconi syndrome with myeloma, demonstrating the deposition of the variable domain in the proximal tubules of the kidney.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1350-6129
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-20
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
V-domain deposition of lambda Bence Jones protein in the renal tubular epithelial cells in a patient with the adult Fanconi syndrome with myeloma.
pubmed:affiliation
Third Department of Medicine, Kobe University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Case Reports