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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1998-10-16
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pubmed:abstractText |
Hydroalcoholic hypericum extract inhibits the synaptosomal uptake of serotonin, norepinephrine, and dopamine with about similar affinities and leads to a significant down-regulation of cortical beta-adrenoceptors and 5-HT2-receptors after subchronic treatment of rats. While neither hypericine nor kaempferol did show any reuptake inhibiting properties, hyperforin was identified as the unspecific reuptake inhibitor of hypericum extracts with half-maximal inhibitory concentrations for the three synaptosomal uptake systems mentioned above between 80 and 200 nmol/l. Moreover, a hyperforin-enriched (38%) CO2 extract also leads to a significant beta-receptor down-regulation after subchronic treatment. The data suggest hyperforin as the active principle of hypericum extracts in biochemical models of antidepressant activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Perylene,
http://linkedlifedata.com/resource/pubmed/chemical/Phloroglucinol,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Quercetin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes,
http://linkedlifedata.com/resource/pubmed/chemical/hyperforin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0176-3679
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9684943-Animals,
pubmed-meshheading:9684943-Bicyclo Compounds,
pubmed-meshheading:9684943-Brain,
pubmed-meshheading:9684943-Dopamine,
pubmed-meshheading:9684943-Female,
pubmed-meshheading:9684943-Hypericum,
pubmed-meshheading:9684943-Male,
pubmed-meshheading:9684943-Mice,
pubmed-meshheading:9684943-Monoamine Oxidase,
pubmed-meshheading:9684943-Neurotransmitter Uptake Inhibitors,
pubmed-meshheading:9684943-Norepinephrine,
pubmed-meshheading:9684943-Perylene,
pubmed-meshheading:9684943-Phloroglucinol,
pubmed-meshheading:9684943-Plant Extracts,
pubmed-meshheading:9684943-Plants, Medicinal,
pubmed-meshheading:9684943-Quercetin,
pubmed-meshheading:9684943-Rats,
pubmed-meshheading:9684943-Rats, Wistar,
pubmed-meshheading:9684943-Receptors, Adrenergic, beta,
pubmed-meshheading:9684943-Receptors, Serotonin,
pubmed-meshheading:9684943-Serotonin,
pubmed-meshheading:9684943-Synaptosomes,
pubmed-meshheading:9684943-Terpenes,
pubmed-meshheading:9684943-Xanthenes
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pubmed:year |
1998
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pubmed:articleTitle |
Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.
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pubmed:affiliation |
Department of Pharmacology, Biocenter University of Frankfurt, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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