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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-9-21
|
| pubmed:abstractText |
Experiments were conducted to determine whether following genetic damage at germ cell stages induced by paternal exposure to 252Cf fission neutron could lead to tumorigenesis in the offspring. Seven-week-old C3H/HeNCrj male mice were irradiated with 252Cf fission neutrons, at doses of 0 and 12.5 cGy and were mated with nine-week-old C57BL/6NCrj females two weeks after the exposure. Three weeks later, it was found that the proportion of abnormal sperm in the 12.5 cGy-irradiated males was higher than that of 0 cGy-irradiated group. Embryo lethality among the F1 offspring was also found to be higher in the 12.5 cGy group than in the 0 cGy group, while the incidence of liver tumors among the F1 offspring increased in males only. These results suggest that the paternal 12. 5 cGy radiation exposure may have caused genetic transmission of liver tumor-associated traits, which is in line with findings that show steep increase in incidence of tumorigenesis in B6C3F1.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1021-335X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1175-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9683830-Animals,
pubmed-meshheading:9683830-Body Weight,
pubmed-meshheading:9683830-Californium,
pubmed-meshheading:9683830-Crosses, Genetic,
pubmed-meshheading:9683830-Female,
pubmed-meshheading:9683830-Fetal Death,
pubmed-meshheading:9683830-Incidence,
pubmed-meshheading:9683830-Liver Neoplasms,
pubmed-meshheading:9683830-Male,
pubmed-meshheading:9683830-Mice,
pubmed-meshheading:9683830-Mice, Inbred C3H,
pubmed-meshheading:9683830-Mice, Inbred C57BL,
pubmed-meshheading:9683830-Neoplasms, Radiation-Induced,
pubmed-meshheading:9683830-Neutrons,
pubmed-meshheading:9683830-Organ Size,
pubmed-meshheading:9683830-Ovary,
pubmed-meshheading:9683830-Paternal Exposure,
pubmed-meshheading:9683830-Pregnancy,
pubmed-meshheading:9683830-Spermatozoa,
pubmed-meshheading:9683830-Testis
|
| pubmed:articleTitle |
Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation.
|
| pubmed:affiliation |
Department of Environment and Mutation, Division of Environmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
|
| pubmed:publicationType |
Journal Article
|