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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-8-6
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pubmed:abstractText |
The Fas receptor (APO-1/CD95) is capable of inducing apoptosis of lymphoid cells and is expressed in some non-Hodgkin's lymphomas (NHLs). Fas expression is up-regulated at the surface of normal B cells upon triggering of the CD40 receptor. In this report, we investigated the sensitivity of NHLs to Fas-mediated apoptosis induced by anti-Fas monoclonal antibodies (MAbs) and its possible modulation by CD40 ligation in 18 NHL biopsy samples of various histological subtypes. Flow cytometric analysis showed that the fraction of Fas-expressing lymphoma cells was highly variable from sample to sample (from 1% to 93%, mean value 46%). The frequency of apoptotic cells was not significantly increased upon treatment with an anti-Fas MAb compared with control MAb in the 18 NHL cases analysed. The sensitivity of lymphoma cells to Fas-mediated apoptosis was correlated neither with the histological subtypes nor with the level of Fas expression. Activation of neoplastic B cells by CD40 ligation resulted in significant increases in Fas expression and Fas-induced apoptosis among the five B-NHL cases tested. The overall increase in apoptotic rates was moderate and remained lower in tumour samples than in control CD40-activated normal tonsil B cells. Altogether, our results indicate that the sensitivity to Fas-induced apoptosis is null or weak in NHL cells, irrespective of their histological subtype, and that it can be increased to a moderate and variable degree by CD40 ligation on neoplastic B cells. This may be an impediment to the development of Fas-based therapies for NHLs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-1372394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-1375228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-1498330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-1689786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-1713127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-3924412,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7520027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7540067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7545115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7595197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7595225,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7684622,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7889405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-7917108,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-8207254,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9683298-9531598
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1998
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pubmed:articleTitle |
Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation.
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pubmed:affiliation |
Department of Hematopathology, Institut Paoli-Calmettes, Marseilles, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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