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pubmed-article:9683014pubmed:abstractTextThis study was performed to examine the roles of body temperature, NMDA receptors and nitric oxide (NO) synthase in post-ischemic retinal injury in rats. Cell loss in the ganglion cell layer and thinning of the inner plexiform layer were observed 7 days after ischemia. Cell loss in the ganglion cell layer but not thinning of the inner plexiform layer was reduced by hypothermia during ischemia. Intravenous injection of dizocilpine (MK-801) or Nomega-nitro-L-arginine methyl ester (L-NAME) prior to ischemia ameliorated retinal injury. These results suggest that activation of NO synthase following NMDA receptor stimulation is involved in ischemia-induced retinal injury.lld:pubmed
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pubmed-article:9683014pubmed:articleTitleInhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina.lld:pubmed
pubmed-article:9683014pubmed:affiliationDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.lld:pubmed
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