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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11-12
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pubmed:dateCreated |
1998-10-22
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pubmed:abstractText |
The current human whole-cell vaccine is ineffective against pneumonic plague caused by typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to also be ineffective against F1-negative (F1-) Y. pestis strains, which have been isolated from a human case and from rodents. For these reasons, the authors developed a recombinant vaccine composed of a fusion protein of F1 with a second protective immunogen, V antigen. This vaccine protected experimental mice against pneumonic as well as bubonic plague produced by either an F1+ or F1- strain of Y. pestis, gave better protection than F1 or V alone against the F1+ strain, and may provide the basis for an improved human plague vaccine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1131-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9682370-Aerosols,
pubmed-meshheading:9682370-Animals,
pubmed-meshheading:9682370-Antigens, Bacterial,
pubmed-meshheading:9682370-Bacterial Capsules,
pubmed-meshheading:9682370-Female,
pubmed-meshheading:9682370-Humans,
pubmed-meshheading:9682370-Injections, Subcutaneous,
pubmed-meshheading:9682370-Mice,
pubmed-meshheading:9682370-Molecular Weight,
pubmed-meshheading:9682370-Plague,
pubmed-meshheading:9682370-Recombinant Fusion Proteins,
pubmed-meshheading:9682370-Species Specificity,
pubmed-meshheading:9682370-Vaccines, Synthetic
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pubmed:year |
1998
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pubmed:articleTitle |
Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine.
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pubmed:affiliation |
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
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pubmed:publicationType |
Journal Article
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